Anti-MIB2 antibody
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概述
- 产品描述E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene. pathway:Protein modification; protein ubiquitination. PTM:Ubiquitinated. Possibly via autoubiquitination. Contains 1 ZZ-type zinc finger. Contains 2 MIB/HERC2 domains. Contains 2 RING-type zinc fingers. Contains 9 ANK repeats. subcellular location:Colocalizes with endosomal compartments. subunit:Interacts with actin monomer. tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
- 产品名称Anti-MIB2 antibody
- 分子量111 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from part region of human protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
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特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
