Anti-PLXB1 antibody
-
概述
- 产品描述disease:Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth. Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. Belongs to the plexin family. Contains 1 Sema domain. Contains 3 IPT/TIG domains. subunit:Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2. tissue specificity:Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.
- 产品名称Anti-PLXB1 antibody
- 分子量234 kDa
- 种属反应性Human,Mouse
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from human protein . at AA range: 90-170
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
-
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
