Anti-PPM1Dantibody
-
概述
- 产品描述The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
- 产品名称Anti-PPM1D antibody
- 分子量67 KDa
- 种属反应性Human,Mouse,Rat,Chicken,Dog,Pig,Cow
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human PPM1D 201-300/605
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Cytosol, Nucleus.
- 其它名称WPP-DOMAIN INTERACTING PROTEIN 1
EC 3.1.3.16
p53 induced protein phosphatase 1
PP2C delta
PP2CD
protein phosphatase 1D magnesium-dependent delta isoform
Protein phosphatase 2C delta isoform
Protein phosphatase 2C isoform delta
Protein phosphatase magnesium dependent 1 delta
WIP 1
WIP1
AV338790
PPM1D
PPM1D_HUMAN.
more
-
-
Fig1: Sample:
Hela(Human) Cell Lysate at 30 ug
Primary: Anti-PPM1D at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 67 kD
Observed band size: 67 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
