Anti-GCSF Receptor antibody
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概述
- 产品描述The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. The class IV isoform defective for both internalization and differentiation signaling. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.
- 产品名称Anti-GCSF Receptor antibody
- 分子量95 KDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human G-CSFR 101-200/863
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Isoform 2: Secreted (Probable). Cell membrane; Single-pass type I membrane protein.
- 其它名称GCSF Receptor
CD 114
CD114
CD114 antigen
Colony stimulating factor 3 receptor (granulocyte)
Colony stimulating factor 3 receptor
CSF 3R
CSF3R
CSF3R_HUMAN
Csfgr
G CSF R
G-CSF receptor
G-CSF-R
G-CSFR
GCSFR
Granulocyte colony stimulating factor receptor
Granulocyte colony stimulating factor receptor precursor
Granulocyte colony-stimulating factor receptor.
more
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Fig1: Sample: 293T Cell (Human) Lysate at 30 ug
Primary: Anti- GCSF Receptor at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 95kD
Observed band size: 120kD
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