Anti-CD209/DC-SIGN antibody
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概述
- 产品描述Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
- 产品名称Anti-CD209/DC-SIGN antibody
- 分子量45 KDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from mouse DC-SIGN/CD209 81-180/238
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Isoform 1, 2, 3, 4, 5, : Cell membrane; Single-pass type II membrane protein (Probable). Isoform 6, 7, 8, 9, 10, 11, 12: Secreted (Probable).
- 其它名称CLEC4L
Dendritic cell-specific ICAM-3-grabbing non-integrin 1
C type lectin domain family 4 member L
CD 209
CD209
CD209 antigen
CD209 antigen-like protein A
CD209 molecule
Cd209a
CDSIGN
CIRE
DC SIGN1
DC-SIGN
DCSIGN
Dendritic cell specific ICAM 3 grabbing nonintegrin 1
Dendritic cell specific ICAM3 grabbing nonintegrin 1
Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
Dengue fever, protection against, included
Dentritic Cell Specific ICAM3 Grabbing Nonintegrin
HIV GP120 Binding Protein
MGC129965
MGC130443
SIGN-R1
SIGNR5
C209A_MOUSE.
more
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Fig1: Sample:Raji Cell (Human) Lysate at 40 ug
Primary: Anti-CD209at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45kD
Observed band size: 47kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
