Anti-复 antibody
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概述
- 产品描述The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Antithrombin III (ATIII), an extracellular plasma protein, is a crucial serine protease inhibitor that regulates the coagulation cascade in blood. The inhibitory activity of ATIII is amplified in the presence of heparin. ATIII inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia.
- 产品名称Anti-SERPINC1 antibody
- 分子量53 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Recombinant protein within human SERPINC1 aa 150-400.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified.
- 亚细胞定位Secreted.
- 其它名称ANT3_HUMAN antibody
Antithrombin antibody
Antithrombin III antibody
Antithrombin-III antibody
AntithrombinIII antibody
AT 3 antibody
AT III antibody
AT3 antibody
AT3D antibody
ATIII antibody
Heparin cofactor I antibody
MGC22579 antibody
Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody
Serine cysteine proteinase inhibitor clade C member 1 antibody
Serine proteinase inhibitor clade C member 1 antibody
Serpin C1 antibody
Serpin family C member 1 antibody
Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody
SERPINC1 antibody
THPH7 antibody
more
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应用
WB: 1:500-1;1,000
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis of SERPINC1 on different lysates using anti-SERPINC1 antibody at 1/500 dilution.
Positive control:
Lane 1: HepG2
Lane 2: Mouse smooth muscle
Lane 3: Mouse lung
Fig2: ICC staining SERPINC1 in H22 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining SERPINC1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-SERPINC1 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-SERPINC1 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded human small intestine tissue using anti-SERPINC1 antibody. Counter stained with hematoxylin.
Fig7: Flow cytometric analysis of HepG2 cells with SERPINC1 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the s
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