Anti-BCHE antibody
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概述
- 产品描述Present in most cells except erythrocytes, butyrylcholine esterase (BChE), also designated acylcholine acylhydrolase or pseudocholinesterase, has esterase activity as well as aryl acylamidase activity. It hydrolyzes acylcholine into choline and carboxylate. BChE is synthesized in the liver and is highly reactive with organophosphate esters. BChE can form a homotetramer composed of two dimers linked by a disulfide bond. Defects in the gene encoding BChE are associated with the disease hypocholinesterasemia. Inhibition of BChE effects the toxicity of organophosphates in the respiratory system suggesting that BChE may play a role in respiratory function. In addition, BChE may play an important pharmocological role by hydrolyzing toxic esters. This suggests an involvement of BChE in a treatment for intoxication with substances such as cocaine.
- 产品名称Anti-BCHE antibody
- 分子量68 kDa
- 种属反应性Human
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原Recombinant protein within Human BCHE aa 300-500.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified.
- 亚细胞定位Secreted.
- 其它名称Acylcholine acylhydrolase antibody
BCHE antibody
Butyrylcholine esterase antibody
CHE1 antibody
CHE2 antibody
CHLE_HUMAN antibody
Choline esterase II antibody
Cholinesterase (serum) 2 antibody
Cholinesterase 1 antibody
Cholinesterase antibody
E1 antibody
Pseudocholinesterase antibody
Pseudocholinesterase E1 antibody
more
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应用
WB: 1:500-1:2,000
ICC: 1:50-1:200
IHC-P: 1:50-1:200
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Fig1: Western blot analysis of BCHE on human blood plasma using anti-BCHE antibody at 1/1,000 dilution.
Fig2: ICC staining BCHE in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining BCHE in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-BCHE antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-BCHE antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-BCHE antibody. Counter stained with hematoxylin.
Fig7: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-BCHE antibody. Counter stained with hematoxylin.
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