Anti-Cleaved-Tumstatin (P1426) antibody
-
概述
- 产品描述Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r
- 产品名称Anti-Cleaved-Tumstatin (P1426) antibody
- 分子量27 kDa
- 种属反应性Human, Monkey
- 验证应用WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:1407-1456
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 亚细胞定位Basement membrane
- 其它名称COL4A3 antibody; Collagen alpha-3(IV) chain antibody; Goodpasture antigen antibody;
-
-
Fig1: Western Blot analysis of various cells using Cleaved-Tumstatin (P1426) Polyclonal Antibody
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
