Anti-Fibrinogen antibody
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概述
- 产品描述The plasma glycoprotein Fibrinogen is synthesized in the liver and comprises three structurally different subunits: a, b and g. Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e. the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.
- 产品名称Anti-Fibrinogen antibody
- 分子量70/55 kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,FC
- 抗体类型兔多抗
- 免疫原Native protein.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein A purified.
- 亚细胞定位Secreted.
- 其它名称FGA antibody
Fib2 antibody
FIBA_HUMAN antibody
Fibrinogen A alpha polypeptide antibody
Fibrinogen alpha chain antibody
Fibrinogen B alpha polypeptide antibody
Fibrinogen beta chain antibody
Fibrinogen G alpha polypeptide antibody
Fibrinogen gamma chain antibody
fibrinogen, B beta polypeptide antibody
fibrinogen, G gamma polypeptide antibody
fibrinogen, gamma polypeptide antibody
Fibrinogen--alpha -polypeptide chain antibody
Fibrinogen--beta -polypeptide chain antibody
Fibrinogen--gamma-polypeptide chain antibody
more
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应用
WB: 1:500
ICC: 1:100-1:500
FC: 1:50-1:100
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Fig1: Western blot analysis of Fibrinogen on mouse bone marrow and human kidney tissue lysates using anti-Fibrinogen antibody at 1/500 dilution.
Fig2: ICC staining Fibrinogen in NIH-3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining Fibrinogen in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Flow cytometric analysis of NIH-3T3 cells with Fibrinogen antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
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