Anti-LOX-1 antibody
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概述
- 产品描述The oxidized low density lipoprotein (lectin-like) receptor-1, Ox-LDL R-1, is a type II membrane protein that is a member of the C-type lectin family and acts as a cell-surface receptor for oxidized low density lipoprotein (Ox-LDL). Ox-LDL plays a role in early atherosclerosis, which includes the transformation of monocyte-derived macrophages to foam cells in atherosclerotic lesions. The binding of Ox-LDL to Ox-LDL R-1 may also trigger the activation of the NFkB signal transduction pathway. Ox-LDL R-1, also designated scavenger receptor class E, member 1 (SCARE1); lectin-type oxidized LDL receptor 1 (LOX-1); and CLEC8A), is expressed by vascular endothelial cells, smooth muscle cells and macrophages. It is expressed endogenously as a precursor form with N-linked high mannose carbohydrate chains and as a mature form due to further glycosylation. The N-linked glycosylation of Ox-LDL R-1 appears to be necessary for adequate transportation to the cell surface and efficient ligand binding.
- 产品名称Anti-LOX-1 antibody
- 分子量31 kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Recombinant protein.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified.
- 亚细胞定位Cell membrane. Secreted.
- 其它名称C-type lectin domain family 8 member A antibody
CLEC8A antibody
hLOX 1 antibody
hLOX-1 antibody
Lectin like oxidized LDL receptor 1 antibody
Lectin like oxLDL receptor 1 antibody
Lectin type oxidized LDL receptor 1 antibody
Lectin-like oxidized LDL receptor 1 antibody
Lectin-like oxLDL receptor 1 antibody
Lectin-type oxidized LDL receptor 1 antibody
low density lipoprotein oxidized, receptor 1 antibody
LOX-1 antibody
LOXIN antibody
Olr1 antibody
OLR1_HUMAN antibody
Ox LDL receptor 1 antibody
Ox-LDL receptor 1 antibody
Oxidised low density lipoprotein (lectin like) receptor 1 antibody
Oxidized low density lipoprotein receptor 1 antibody
Oxidized low density lipoprotein receptor 1 soluble form antibody
Oxidized low-density lipoprotein receptor 1 antibody
SCARE1 antibody
Scavenger receptor class E, member 1 antibody
SLOX1 antibody
soluble form antibody
SR-EI antibody
more
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应用
WB: 1:500-1:1,000
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis of LOX1 on siHa cell lysate using anti-LOX1 antibody at 1/100 dilution.
Fig2: ICC staining LOX1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining LOX1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-LOX1 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-LOX1 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-LOX1 antibody. Counter stained with hematoxylin.
Fig7: Flow cytometric analysis of LOVO cells with LOX1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary
Fig8: Western blot analysis of LOX1 on human lung tissue lysate using anti-LOX1 antibody at 1/500 dilution.
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