Anti-Integrin beta-3 (CD61 antigen) antibody
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概述
- 产品描述Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
- 产品名称Anti-Integrin beta-3 (CD61 antigen) antibody
- 分子量87/110 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Membrane.
- 其它名称Antigen identified by monoclonal antibody L230 antibody
CD 51 antibody
CD 61 antibody
CD51 antibody
CD51 antigen antibody
CD61 antibody
CD61 antigen antibody
DKFZp686A08142 antibody
GP3A antibody
GPIIIa antibody
Integrin alpha V antibody
Integrin alpha V vitronectin receptor alpha polypeptide antibody
Integrin alpha V vitronectin receptor alpha polypeptide antigen CD51 antibody
integrin alpha-V antibody
Integrin alpha-V light chain antibody
Integrin beta 3 antibody
Integrin beta 3 platelet glycoprotein IIIa antigen CD61 antibody
Integrin beta chain beta 3 antibody
integrinVbeta3 antibody
ITAV_HUMAN antibody
ITGAV antibody
ITGB 3 antibody
ITGB3 antibody
MSK 8 antibody
MSK8 antibody
Platelet glycoprotein IIIa antibody
Platelet glycoprotein IIIa precursor antibody
Platelet membrane glycoprotein IIIa antibody
Vitronectin receptor alpha polypeptide antibody
vitronectin receptor antibody
Vitronectin receptor subunit alpha antibody
VNR 1 antibody
VNR1 antibody
VNRA antibody
more
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应用
WB: 1:500-1:1,000
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis of Integrin beta-3 on A431 (1) and rat spleen tissue (2) lysate using anti-Integrin beta-3 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded rat ossature tissue using anti-Integrin beta-3 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Integrin beta-3 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Integrin beta-3 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Integrin beta-3 antibody. Counter stained with hematoxylin.
Fig6: Flow cytometric analysis of A431 cells with Integrin beta-3 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary antibody.
Fig7: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Integrin beta-3 antibody. Counter stained with hematoxylin.
Fig8: Flow cytometric analysis of HUVEC cells with Integrin beta-3 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated Goat
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