Anti-Calcitonin antibody
-
概述
- 产品描述Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Calcitonin has been found in fish, reptiles, birds, and mammals. Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. It belongs to the calcitonin-like protein family. The hormone participates in calcium (Ca2+) and phosphorus metabolism. In many ways, calcitonin counteracts parathyroid hormone (PTH) and vitamin D. High concentrations of calcitonin may be able to increase urinary excretion of calcium and phosphate via the renal tubules.[11] leading to marked hypocalcemia. However, this is a minor effect with no physiological significance in humans. It is also a short-lived effect because the kidneys become resistant to calcitonin, as demonstrated by the kidney's unaffected excretion of calcium in patients with thyroid tumors that secrete excessive calcitonin.
- 产品名称Anti-Calcitonin antibody
- 分子量3.5/13 KDa
- 种属反应性Human,Mouse,Rat,Dog,Rabbit,Guinea Pig
- 验证应用WB,IHC-P
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human Calcitonin 85-116/141
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Secreted.
- 其它名称Alpha CGRP
CALC 1
CALC A
CALC1
CALCA
Calcitonin related polypeptide alpha
CGRP 1
CGRP
CGRP I
CGRP-1
CGRPI
CGRP1
CT
Katacalcin
KC
MGC126648
alpha type CGRP
calcitonin 1
calcitonin gene related peptide 1
calcitonin gene related peptide I
calcitonin isoform CT preproprotein.
more
-
应用
WB:1:500-2000
IHC-P:1:400-800
-
Fig1: Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37℃ for 30min; Antibody incubation with (Calcitonin) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4℃, followed by operating according to SP Kit (Rabbit) (sp-0023) instructionsand DAB staining.
Fig2: Sample:
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti-Calcitonin at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 3.5/13 kD
Observed band size: 17 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
