Anti-TBCC antibody

Anti-TBCC antibody

• 概述

• 产品描述Microtubules, the primary component of the cytoskeletal network, are highly dynamic structures composed of α/β Tubulin heterodimers. Biosynthesis of functional microtubules involve the participation of several chaperones, termed tubulin folding cofactors A (TBCA), D (TBCD), E (TBCE) and C (TBCC), that act on folding intermediates downstream of the cytosolic chaperonin, alternatively named TCP. TBCC (Tubulin-specific chaperone C), also known as β Tubulin-folding cofactor C or CFC, is a 346 amino acid protein belonging to the TBCD family. Interaction with TBCC causes the release of tubulin polypeptides that are committed to the native state. TBCC shares significant homology with X-linked retinitis pigmentosa 2 gene RP2, in which mutations cause the progressive degeneration of photoreceptor cells.

• 产品名称Anti-TBCC antibody

• 分子量39 kDa

• 种属反应性Human

• 验证应用WB,IHC-P,ICC

• 抗体类型小鼠单抗

• 免疫原Recombinant protein

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度2 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

• 亚型IgG1

• 纯化方式Protein A purified.

• 亚细胞定位Cytoplasm. Cytoskeleton.

   

• 其它名称

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  • Beta tubulin cofactor C antibody

  • CFC antibody

  • TBCC antibody

• 应用

  WB: 1:500-1:2,000
  ICC: 1:50-1:200
  IHC-P: 1:50-1:200

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  Fig1: Western blot analysis of TBCC on human TBCC recombinant protein using anti-TBCC antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of TBCC on HEK293 (1) and TBCC-hIgGFc transfected HEK293 (2) cell lysate using anti-TBCC antibody at 1/1,000 dilution.

   

  

  Fig3: ICC staining TBCC (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-TBCC antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue using anti-TBCC antibody. Counter stained with hematoxylin.

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