Anti-CD93 antibody [E10-A10]

Anti-CD93 antibody [E10-A10]

• 概述

• 产品描述The CD93 antigen is a 652 amino acid cell-surface glycoprotein expressed by monocytes, neutrophils, platelets, microglia, and endothelial cells. CD93 was originally thought to be a putative receptor for the complement component C1q, a serum glycoprotein which plays an integral role in the activation of the classical pathway in response to immune complexes. As a result, in the literature the CD93 gene product has also been referred to as C1QR1 and C1qRp as well as MXRA4 (Matrix-remodeling-associated protein 4). Recent studies suggest that the CD93 antigen plays a role in intercellular adhesion and in clearance of apoptotic cells. CD93 is a heavily O-glycosylated, type I transmembrane protein consisting of an N-terminal domain with homology to C-type lectin domains, a tandem array of EGF-like domains, a single transmembrane domain and a short cytoplasmic tail.

• 产品名称Anti-CD93 antibody [E10-A10]

• 分子量69 kDa

• 种属反应性Human

• 验证应用WB,ICC,IHC-P,FC

• 抗体类型小鼠单抗

• 免疫原Recombinant protein

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度2 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

• 亚型IgG1

• 纯化方式Protein A purified.

• 亚细胞定位Membrane.

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• ​其它名称

  more

  • C1q receptor 1 antibody

  • C1q/MBL/SPA receptor antibody

  • C1qR antibody

• 应用

  WB: 1:500-1:1,000
  ICC: 1:50-1:200
  IHC-P: 1:50-1:200
  FC: 1:100-1:200

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  Fig1: Western blot analysis of CD93 on human CD93 recombinant protein using anti-CD93 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of CD93 on HEK293 (1) and CD93-hIgGFc transfected HEK293 (2) cell lysate using anti-CD93 antibody at 1/1,000 dilution.

   

  

  Fig3: ICC staining CD93 (green) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-CD93 antibody. Counter stained with hematoxylin.

   

  

  Fig5: Flow cytometric analysis of HepG2 cells with CD93 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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