Anti-SEC31A antibody [C6-D12]

Anti-SEC31A antibody [C6-D12]

• 概述

• 产品描述WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Sec31A, also known as ABP125, ABP130 or SEC31L1, is a 1,220 amino acid protein that contains seven WD repeats and localizes to the cytoplasm and to cytoplasmic vesicles, as well as to the membrane of the endoplasmic reticulum (ER). Expressed ubiquitously at high levels, Sec31A functions as a component of the COP II (coat protein II) complex and, working in tandem with other proteins, promotes the formation of ER transport vesicles and aids in the selection of cargo molecules. Chromosomal aberrations that involve the Sec31A gene are associated with inflammatory myofibroblastic tumors (IMTs), suggesting a role for Sec31A in carcinogenesis. Multiple isoforms of Sec31A exist due to alternative splicing events.
• 产品名称Anti-SEC31A antibody [C6-D12]
• 分子量133 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm. Cytoplasmic vesicle.
• 其它名称
  • 1810024J13Rik antibody
  • ABP125 antibody
  • ABP130 antibody
  more

• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:50-1:200

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  Fig1: Western blot analysis of SEC31A on human SEC31A recombinant protein using anti-SEC31A antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of SEC31A on HEK293 (1) and SEC31A-hIgGFc transfected HEK293 (2) cell lysate using anti-SEC31A antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-SEC31A antibody. Counter stained with hematoxylin.

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