Anti-VTN antibody [G11-E8]

Anti-VTN antibody [G11-E8]

• 概述

• 产品描述Fibronectin and Vitronectin are extracellular matrix glycoproteins that are present on most cell surfaces, in extracellular fluids, and in plasma. Both Fibronectin and Vitronectin have been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Vitronectin contains an RGD (Arg-Gly-Asp acid) sequence that is present in many cell adhesion ligands. The RGD sequence has been shown to be essential for cell adhesion. Increased expression of Vitronectin, integrins and plasminogen activators has been observed in migrating cells during wound healing. Vitronectin has been shown to enhance smooth cell migration, and PAI-1 has been shown to bind to Vitronectin with high affinity, resulting in the blocking of smooth cell migration. Glycosaminoglycans, proteins involved in the anchoring of vitronectin to the extracellular matrix, have been shown to stimulate the cleavage of vitronectin by plasmin. This cleavage reduces the affinity of vitronectin for PAI-1.
• 产品名称Anti-VTN antibody [G11-E8]
• 分子量54 kDa
• 种属反应性Human
• 验证应用WB,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein A purified.
• 亚细胞定位Secreted, extracellular space
• 其它名称
  • Complement S Protein antibody
  • Epibolin antibody
  • S Protein antibody
  more

• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:50-1:200
  FC: 1:50-1:100

•  

  

  Fig1: Western blot analysis of VTN on human VTN recombinant protein using anti-VTN antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of VTN on HEK293 (1) and VTN-hIgGFc transfected HEK293 (2) cell lysate using anti-VTN antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-VTN antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-VTN antibody. Counter stained with hematoxylin.

   

  

  Fig5: Flow cytometric analysis of Hela cells with VTN antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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