Anti-HOXB4 antibody [2F-2A]

Anti-HOXB4 antibody [2F-2A]

• 概述

• 产品描述The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Encoded by the HOXB4 gene, the nuclear phosphoprotein HoxB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation. Hematopoietic expression of HoxB4 is regulated by the binding of USF-1 and USF-2, the binding of which may be favored by cytokines promoting stem cell self-renewal versus differentiation. HoxB4 is dependent on AP-1 expression to induce changes in cellular proliferation and differentiation, which increases the levels of cyclin D1, thereby linking HoxB4 with key elements of the cell cycle machinery. HoxB4 also participates in the down-regulation of c-Myc expression. It is expressed in developing hair follicles as well as in K-562 and HL-60 cells.
• 产品名称Anti-HOXB4 antibody [2F-2A]
• 分子量28 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2a
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus.
• 其它名称
  • Homeo box 2F antibody
  • Homeo box B4 antibody
  • Homeobox 2F antibody
  more

• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:200-1:1,000

•  

  

  Fig1: Western blot analysis of HOXB4 on human HOXB4 recombinant protein using anti-HOXB4 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of HOXB4 on HEK293 (1) and HOXB4-hIgGFc transfected HEK293 (2) cell lysate using anti-HOXB4 antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-HOXB4 antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-HOXB4 antibody. Counter stained with hematoxylin.

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