Anti-MAP3K7 antibody [1G5]

Anti-MAP3K7 antibody [1G5]

• 概述

• 产品描述Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine/ threonine residues and that is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase sup-pressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFβ-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFβ stimulation.
• 产品名称Anti-MAP3K7 antibody [1G5]
• 分子量70 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原Amino acids 1-579 representing full length Tak1 (TGFβ-activated kinase) of mouse origin.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm, Cell membrane
• 其它名称
  • M3K7_HUMAN antibody
  • MAP3K 7 antibody
  • Map3k7 antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500

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  Fig1: Western blot analysis of Tak1 expression in non-transfected (A) and mouse Tak1 transfected (B) 293T whole cell lysates.

   

  

  Fig2: Western blot analysis of Tak1 expression in non-transfected 293 (A), human Tak1 transfected 293 (B) and 3611-RF (C) whole cell lysates.

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