Anti-WNT4 antibody [4G1]

Anti-WNT4 antibody [4G1]

• 概述

• 产品描述Products of the highly conserved Wnt gene family, including Wnt-1 through Wnt-10, play key roles in regulating cellular growth and differentiation. Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1, which is essential for normal development of the embryonic nervous system, contributes to hyperplasia and tumorigenic progression when improperly expressed in mammary tissue. Wnt-3 is also involved in tumorigenesis, and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue.Wnt-1, Wnt-3 and Wnt-10b have been implicated along with FGF-3 in the development of mouse mammary tumor virus-induced mouse mammary carcinomas.Wnt family members have been shown to interact with Sonic hedgehog (Shh) in vivo to induce myogenesis in somitic tissue.
• 产品名称Anti-WNT4 antibody [4G1]
• 分子量40 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted
• 其它名称
  • MGC123964 antibody
  • Protein Wnt-4 antibody
  • RP23-246F18.1 antibody
  more

• 应用

  WB: 1:1,000
  IP: 1-2 μg per 100-500 μg of total protein
  IF: 1:50-500
  IHC-P: 1:50-500

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  Fig1: Western blot analysis of Wnt-4 expression in L929 (A) CSMLO (B), ESD3 (C) and ESD5 (D) whole cell lysates.

   

  

  Fig2: Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in white pulp.

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