Anti-GABA(B) R2 antibody [3G3]
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概述
- 产品描述In the central nervous system (CNS), γ-aminobutyric acid (GABA) is the maininhibitory neurotransmitter that functions to regulate neuronal firing. GABAexerts its effects through two different kinds of receptors: ionotropic receptors(GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropicreceptors (GABAB R), which produce slow inhibitory signals. TheGABAB R receptor is a heterodimer that consists of two multi-pass membraneproteins, designated GABAB R1 and GABAB R2, both of which belong to theG protein-coupled receptor family and are highly expressed in brain tissue.Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning ofinhibitory synaptic transmissions and are implicated in slow wave sleep,muscle relaxation, hippocampal long-term potentiation and antinociceptionevents. Both GABAB R1 and GABAB R2 are regulated by G proteins that havea variety of functions, including activation of potassium channels, inhibitionof adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipidhydrolysis.
- 产品名称Anti-GABA(B) R2 antibody [3G3]
- 分子量130 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IP,IF
- 抗体类型小鼠单抗
- 免疫原Amino acids 183-482 mapping within an extracellular domain of GABA(B) R2 of human origin.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG1
- 纯化方式Protein A purified.
- 亚细胞定位--
- 其它名称
- BcDNA:GH07312 antibody
- CG6706 antibody
- CT20836 antibody
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应用
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
IF: 1:50-500
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Fig1: W Western blot analysis of GABAB R2 expression in mouse brain (A) and rat brain (B) tissue extracts.
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