Anti-HSP27 antibody [10-8]

Anti-HSP27 antibody [10-8] 

• 概述

• 产品描述Hsp27 is a chaperone of the sHsp(small heat shock protein) group among ubiquitin, α-crystallin,Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and?cell differentiation. They also take part in signal transduction. The main function of Hsp27 is to provide thermotolerance in vivo, cytoprotection, and support of cell survival under stress conditions. More specialized functions of Hsp27 are manifold and complex. In vitro it acts as an ATP-independent chaperone by inhibiting protein aggregation and by stabilizing partially denatured proteins, which ensures refolding by the Hsp70-complex. Hsp27 is also involved in the apoptotic signalling pathway. Hsp27 interacts with the outer mitochondrial membranes and interferes with the activation of?cytochrome c/Apaf-1/dATP complex and therefore inhibits the activation of procaspase-9.
• 产品名称Anti-HSP27 antibody [10-8]
• 分子量25 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,ICC,IHC-P
• 抗体类型小鼠单抗
• 免疫原recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm, nucleus
• 其它名称
  • Heat shock 27kDa protein antibody
  • 28 kDa heat shock protein antibody
  • CMT2F antibody
  more

• 应用

  WB: 1:1,000-1:2,000
  ICC: 1:200

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  Fig1: Western blot analysis on different cell lysates using anti-HSP27 mouse mAb.

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