Anti-MTHFR antibody [F3-D5]

Anti-MTHFR antibody [F3-D5]

• 概述

• 产品描述5,10-methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate-dependent regulation of methionine and homocysteine concentrations. MTHFR catalyzes the reduction of 5,10-methylenetetrahydrofolate (methyleneTHF) to 5- methyltetrahydrofolate (methylTHF). MethylTHF, the predominate form of circulating folate, is the principle carbon donor for homocysteine methylation, a reaction that yields methionine. Folate prevents neural tube defects, and can lower homocysteine levels, suggesting that MTHFR function is important in preventing cardiovascular disease. Mutations at the MTHFR gene may influence vascular changes, predisposition to leukemia, coronary artery disease and hyperhomocysteinemia.
• 产品名称Anti-MTHFR antibody [F3-D5]
• 分子量75 kDa
• 种属反应性Human,Rat
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytosol.
• 其它名称
  • 5 10 methylenetetrahydrofolate reductase (NADPH) antibody
  • 5 10 methylenetetrahydrofolate reductase antibody
  • Methylenetetrahydrofolate reductase (NAD(P)H) antibody
  more

• 应用

  WB: 1:500
  IHC-P: 1:50-1:200

•  

  

  Fig1: Western blot analysis of MTHFR on rat heart tissue lysate using anti-MTHFR antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of MTHFR on HEK293 (1) and MTHFR-hIgGFc transfected HEK293 (2) cell lysate using anti-MTHFR antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-MTHFR antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human intima cancer tissue using anti-MTHFR antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-MTHFR antibody. Counter stained with hematoxylin.

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