Anti-Alpha Tubulin antibody
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概述
- 产品描述Microtubules are essential parts in eukaryotic cell structures, transportation, and mitosis. It consists mainly of 2 soluble protein subunits, alpha and beta tubulin. Beta tubulin binds to alpha tubulin to form tubulin heterodimer which is post-translationally modified (1). The tubulin dimer complex binds to GTP and assembles onto the positive ends of microtubules. After incorporation into the microtubules, bound GTP is hydrolyzed by beta tubulin. The stability of the dimer in the microtubules is depended on presence of beta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubule incorporation (2). For both type of tubulin, the carboxy-terminal tail is post-translationally modified to regulate associated protein binding at microtubule surface (3). A mutation on alpha tubulin has been linked to abnormal neuronal migration and neurodevelopmental disorders in humans (4).
- 产品名称Anti-Alpha Tubulin antibody [6J8]
- 分子量50 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P,IP
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20 ℃. Stable for 12 months from date of receipt
- 存储缓冲液1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Tissue culture supernatant
- 亚细胞定位Cytoplasm
- 其它名称
- Alpha tubulin ubiquitous antibody
- Alpha-tubulin ubiquitous antibody
- K alpha 1 antibody
more
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应用
WB: 1:1,000
ICC: 1:100
IHC-P: 1:100
IP: 1:10-100
FC: 1:10-100
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Fig1: Western blot analysis on HeLa cell lysate using anti- alpha-Tubulin.
Fig2: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma using anti- alpha-Tubulin.
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