Anti-Cytokeratin 8 antibody
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概述
- 产品描述Keratins, the intermediate filament proteins of epithelial cells, connect to desmosomes, the cell-cell adhesion structures at the surface membrane. Among the various intermediate filament (IF) proteins, cytokeratin 8 (CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, and can also be synthesized in certain non-epithelial cells. Keratin 8 and 18 (CK8/18) are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. While K8/K18 are essential for maintaining structural integrity, there is accumulating evidence indicating that they also exert non-mechanical functions. It has been reported that K8/K18-free hepatocytes from K8-null mice are more sensitive to Fas-mediated apoptosis, in line with an increased Fas density at the cell surface and an altered c-Flip regulation of the anti-apoptotic ERK1/2 signaling pathway.
- 产品名称Anti-Cytokeratin 8 antibody
- 分子量52kDa
- 种属反应性Human
- 验证应用WB,ICC,IHC-P,FC,IP
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20 ℃. Stable for 12 months from date of receipt
- 存储缓冲液1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Tissue culture supernatant
- 亚细胞定位Cytoplasm, Nucleus, Nucleus matrix
- 其它名称
- CARD2 antibody
- CK 8 antibody
- CK-8 antibody
more
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应用
WB: 1:1,000
ICC: 1:100
IHC-P: 1:100-250
IP: 1:50
FC: 1:20
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Fig1: Western blot analysis on A431 cell lysate using anti-CK8 RabMAb.
Fig2: Immunofluorescent staining of HeLa cells using anti-CK8 RabMAb.Immunohistochemical analysis of paraffin-embedded human breast adenocarcinoma using anti-CK8 RabMAb.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
