Anti-Smad2 antibody
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概述
- 产品描述Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad proteins.
- 产品名称Anti-Smad2 antibody
- 种属反应性Human,Mouse,Rat
- 验证应用ICC,IHC-P
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Cytoplasm, Nucleus
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应用
ICC: 1:50-1:100
IHC-P:1:50-1:200
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Fig1: Immunocytochemical staining of SW480 cells using anti-Smad2 rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of SK-BR-3 cells using anti-Smad2 rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of HepG2 cells using anti-Smad2 rabbit polyclonal antibody.
Fig4: Immunohistochemical analysis of paraffin- embedded human liver cancer tissue using anti-Smad2 rabbit polyclonal antibody.
Fig5: Immunohistochemical analysis of paraffin- embedded mouse skeletal muscle tissue using anti-Smad2 rabbit polyclonal antibody.
Fig6: Immunohistochemical analysis of paraffin- embedded mouse placenta tissue using anti-Smad2 rabbit polyclonal antibody.
Fig7: Immunohistochemical analysis of paraffin- embedded mouse heart tissue using anti-Smad2 rabbit polyclonal antibody.
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