Anti-Smad2 antibody
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概述
- 产品描述Smad 2 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, nine Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 2 and 3 serve as pathway-restricted Smads for the TGF-beta/activin signaling pathways. Smad 2 is phosphorylated by the TGF-beta type 1 receptor kinase on Ser 465 and Ser 467. Phosphorylation of both serines is essential for Smad 2-Smad4 heteromeric complex and dissociation of Smad 2 from the TGF-beta type 1 receptor. Once phosphorylated Smad2 translocate to the nucleus where it associates with DNA-binding proteins and forming a transcriptional complex. Unlike Smad 3 and 4, Smad 2 does not directly bind DNA.
- 产品名称Anti-Smad2 antibody
- 分子量58kDa
- 种属反应性Human,Rat
- 验证应用WB,ICC,IHC-P,FC,IP
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20 ℃. Stable for 12 months from date of receipt
- 存储缓冲液1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Tissue culture supernatant
- 亚细胞定位Cytoplasm, Nucleus
- 其它名称
- Drosophila, homolog of, MADR2 antibody
- hMAD-2 antibody
- HsMAD2 antibody
more
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应用
WB: 1:1,000
ICC: 1:100
IHC-P: 1:100
IP: 1:50
FC: 1:30
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Fig1: Western blot analysis on Jurkat cell lysate using anti-Smad2 RabMAb.
Fig2: Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using anti-Smad2 RabMAb.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
