Anti-FPR2 antibody
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概述
- 产品描述The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR like-1 (FPRL1, also designated lipoxin A4 receptor, FPRH1 and FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPRL1 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of b amyloid. Upon activation, FPRL1 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPRL1 may mediate inflammation in prion and Alzheimer’s diseases, which makes it a potential target for therapeutic agents.
- 产品名称Anti-FPR2 antibody
- 分子量50kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Cell membrane
- 其它名称
- ALXR antibody
- FMLP-R-I antibody
- FMLP-R-II antibody
more
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应用
WB: 1:1,000
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis on different lysates using anti-FPR2 rabbit polyclonal antibody. Positive control:
Lane 1: Jurkat
Lane 2: HL-60
Fig2: Immunocytochemical staining of Hela cells using anti-FPR2 rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of PC-3M cells using anti-FPR2 rabbit polyclonal antibody.
Fig4: Immunohistochemical analysis of paraffin- embedded human lung tissue using anti-FPR2 rabbit polyclonal antibody.
Fig5: Immunohistochemical analysis of paraffin- embedded human spleen tissue using anti-FPR2 rabbit polyclonal antibody.
Fig6: Immunohistochemical analysis of paraffin- embedded mouse lung tissue using anti-FPR2 rabbit polyclonal antibody.
Fig7: Immunohistochemical analysis of paraffin- embedded mouse testis tissue using anti-FPR2 rabbit polyclonal antibody.
Fig8: Immunohistochemical analysis of paraffin- embedded mouse spleen tissue using anti-FPR2 rabbit polyclonal antibody.
Fig9: Flow cytometric analysis of Jurkat cells with FPR2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary
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