Anti-Factor IX antibody
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概述
- 产品描述This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
- 产品名称Anti-Factor IX antibody
- 分子量52 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from Factor IX at AA range: 412-461
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain antibody; Coagulation factor IXa heavy chain] antibody;
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Fig1: Western Blot analysis of 3T3 HEPG2 cells using Factor IX Polyclonal Antibody diluted at 1:800. Secondary antibody（catalog#：HA1001) was diluted at 1:20000
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