Anti-SLAM antibody
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概述
- 产品描述domain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues. High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. PTM:Phosphorylated by FYN. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. subcellular location:Present on the surface of B-cells and T-cells. subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A), and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus HN protein and acts as a receptor for this virus. tissue specificity:Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes, and a proportion of B-cells, and is rapidely induced on naive T-cells after activation.
- 产品名称Anti-SLAM antibody
- 分子量37 kDa
- 种属反应性Human
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from the Internal region of human SLAMF1. AA range:81-130
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- SLAMF1 antibody; SLAM antibody; Signaling lymphocytic activation molecule antibody; CDw150 antibody; IPO-3 antibody; CD150 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-300
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Fig1: Western Blot analysis of K562 cells using SLAM Polyclonal Antibody.. Secondary antibody（catalog#：HA1001) was diluted at 1:20000
Fig2: Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:100
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