Anti-ASAH3 antibody
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概述
- 产品描述Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al. 2006
- 产品名称Anti-ASAH3 antibody
- 分子量34 kDa
- 种属反应性Human
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from ASAH3 . at AA range: 100-180
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- ACER1 antibody; ASAH3 antibody; Alkaline ceramidase 1 antibody; AlkCDase 1 antibody; Alkaline CDase 1 antibody; Acylsphingosine deacylase 3 antibody; N-acylsphingosine amidohydrolase 3 antibody;
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Fig1: Western blot analysis of HepG2 using ASAH3 antibody.. Secondary antibody（catalog#：HA1001) was diluted at 1:20000
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