Anti-SIRP-α1/β1 antibody
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概述
- 产品描述The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternati
- 产品名称Anti-SIRP-α1/β1 antibody
- 分子量55 kDa
- 种属反应性Human
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from the Internal region of human SIRPA/SIRPB1. AA range:281-330
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- SIRPA antibody; BIT antibody; MFR antibody; MYD1 antibody; PTPNS1 antibody; SHPS1 antibody; SIRP antibody; Tyrosine-protein phosphatase non-receptor type substrate 1 antibody; SHP substrate 1 antibody; SHPS-1 antibody; Brain Ig-like molecule with tyrosine-based activation motifs antibody; Bit antibody; CD172 antigen-like family member A antibody; Inhibitory receptor SHPS-1 antibody; Macrophage fusion receptor antibody; MyD-1 antigen antibody; Signal-regulatory protein alpha-1 antibody; Sirp-alpha-1 antibody; Signal-regulatory protein alpha-2 antibody; Sirp-alpha-2 antibody; Signal-regulatory protein alpha-3 antibody; Sirp-alpha-3 antibody; p84 antibody; CD172a antibody; SIRPB1 antibody; Signal-regulatory protein beta-1 isoform 3 antibody; SIRP-beta-1 isoform 3 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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Fig1: Western Blot analysis of Hela cells using SIRP-α1/β1 Polyclonal Antibody.. Secondary antibody（catalog#：HA1001) was diluted at 1:20000
Fig2: Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
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