Anti-GAD-65/67 antibody
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概述
- 产品描述This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
- 产品名称Anti-GAD-65/67 antibody
- 分子量65 kDa
- 种属反应性Human, Mouse
- 验证应用WB, IHC-P, IF
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human GAD1/2. AA range:545-594
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称GAD1 antibody; GAD antibody; GAD67 antibody; Glutamate decarboxylase 1 antibody; 67 kDa glutamic acid decarboxylase antibody; GAD-67 antibody; Glutamate decarboxylase 67 kDa isoform antibody; GAD2 antibody; GAD65 antibody; Glutamate decarboxylase 2 antibody; 65 kDa glutamic acid decarboxylase antibody; GAD-65 antibody; Glutamate decarboxylase 65 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
IF: 1:100-1:500
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Fig1: Western Blot analysis of various cells using GAD-65/67 Polyclonal Antibody
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