Anti-FRS2 antibody
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概述
- 产品描述Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. PTM:Phosphorylated on tyrosine residues upon stimulation by NGF. PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. sequence caution:Translated as stop. Contains 1 IRS-type PTB domain. subcellular location:Cytoplasmic, membrane-bound. subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
- 产品名称Anti-FRS2 antibody
- 分子量65 kDa
- 种属反应性Human, Mouse
- 验证应用WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human FRS2. AA range:162-211
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称FRS2 antibody; Fibroblast growth factor receptor substrate 2 antibody; FGFR substrate 2 antibody; FGFR-signaling adaptor SNT antibody; Suc1-associated neurotrophic factor target 1 antibody; SNT-1 antibody;
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Fig1: Western Blot analysis of various cells using FRS2 Polyclonal Antibody diluted at 1：1000
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