Anti-GRC5 antibody
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概述
- 产品描述Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
- 产品名称Anti-GRC5 antibody
- 分子量121 KDa
- 种属反应性Human,Mouse,Rat,Chicken,Horse,Sheep
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human GRC5/PHF2 1001-1096/1096
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Nucleus, nucleolus.
- 其它名称CENP-35
GRC5
PHF2
JHDM1E
Jumonji C domain containing histone demethylase 1E
jumonji containing protein
Lysine-specific demethylase PHF2
PHD finger protein 2
Phf2
PHF2_HUMAN.
more
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Fig1: Sample: 293T Cell (Human) Lysate at 30 ug
Primary: Anti- GRC5at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 121kD
Observed band size: 121kD
Fig2: Sample: HepG2 Cell (Human) Lysate at 30 ug
Primary: Anti- GRC5at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 121kD
Observed band size: 121kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
