Anti-EpCAM antibody
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概述
- 产品描述The epithelial cell adhesion molecule Ep-CAM, which is also designated tumor-associated calcium signal transducer 1 and MK-1, is a monomeric membrane glycoprotein that is expressed in most normal human epithelium and carcinomas. The human Ep-CAM gene encodes a 314 amino acid protein that is expressed as two forms, a major form and a minor form, which are reduced upon treatment with the amino-glycosylation inhibitor tunicamycin. Ep-CAM is overexpressed in a variety of carcinomas and is, therefore, a potential target for the visualization and therapy of human solid tumors. Ep-CAM contains an extracellular domain containing two epidermal growth factor-like repeats, followed by a cysteine poor region, which is necessary for the adhesion properties of the molecule.
- 产品名称Anti-EpCAM antibody
- 分子量35 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原Synthetic peptide within human EpCAM 100-150 aa.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified.
- 亚细胞定位Cell junction. Plasma membrane.
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Epithelial cell surface antigen antibody
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Epithelial glycoprotein 1 antibody
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GA733 1 antibody
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GA733-2 antibody
gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein antibody
gp4 antibody
hEGP 2 antibody
hEGP314 antibody
HNPCC8 antibody
Human epithelial glycoprotein 2 antibody
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KS1/4 antibody
KSA antibody
Ly74 antibody
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M1S2 antibody
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more
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应用
WB: 1:500
ICC: 1:100
IHC-P: 1:50-1:200
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Fig1: Western blot analysis of EpCAM on mouse colon tissue lysate using anti-EpCAM antibody at 1/500 dilution.
Fig2: ICC staining EpCAM in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining EpCAM in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-EpCAM antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-EpCAM antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue using anti-EpCAM antibody. Counter stained with hematoxylin.
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