Anti-FBXL18 antibody
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概述
- 产品描述FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.
- 产品名称Anti-FBXL18 antibody
- 分子量88/40 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified.
- 亚细胞定位Cytoplasm.
- 其它名称F box and leucine rich repeat protein 18 antibody
F box/LRR repeat protein 18 antibody
FBL18 antibody
FBXL 18 antibody
FLJ10776 antibody
FLJ11467 antibody
FLJ26934 antibody
FLJ38075 antibody
FLJ41541 antibody
more
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应用
WB: 1:500
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis of FBXL18 on PC-3M cell lysate using anti-FBXL18 antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-FBXL18 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-FBXL18 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-FBXL18 antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of A549 cells with FBXL18 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
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