Anti-CD21 antibody
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概述
- 产品描述CD21 (also known as complement receptor (CR) type 2) is a type I integral membrane glycoprotein that serves as a receptor for the C3d complement fragment and for the Epstein-Barr virus. It plays a role in B cell activation and proliferation and undergoes phosphorylation after B cell activation with phorbol esters. CD21 is expressed on mature B cells, follicular dendritic cells, pharyngeal and cervical epithelial cells and a subset of thymocytes. The adaptive immune response is tightly regulated to limit responding cells in an antigen-specific manner. On B cells, co-receptors CD21/CD19 modulate the strength of B cell Ag receptor (BCR) signals, thereby influencing cell fate. CD21 is normally expressed during the immature and mature stages of B cell development. In association with CD19, CR21 plays an important role in enhancing mature B cell responses to foreign antigens.
- 产品名称Anti-CD21 antibody
- 种属反应性Human
- 验证应用ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Peptide.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified.
- 亚细胞定位Membrane.
- 其它名称C3DR antibody
CD 21 antibody
CD21 antibody
Complement C3d receptor 2 antibody
Complement C3d receptor antibody
Complement component (3d/Epstein Barr virus) receptor 2 antibody
Complement receptor type 2 antibody
CR antibody
Cr2 antibody
CR2_HUMAN antibody
CVID7 antibody
EBV receptor antibody
EBV-R antibody
Epstein Barr virus receptor antibody
Epstein-Barr virus receptor antibody
EVBR antibody
SLEB9 antibody
more
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应用
IHC-P: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
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Fig1: ICC staining CD21 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig2: ICC staining CD21 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD21 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-CD21 antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of LOVO cells with CD21 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
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