Anti-JAK2 antibody
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概述
- 产品描述JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
- 产品名称Anti-JAK2 antibody
- 分子量131 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用ICC,IHC-P
- 抗体类型兔多抗
- 免疫原Peptide.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified.
- 亚细胞定位Endomembrane system. Nucleus.
- 其它名称JAK 2 antibody
JAK-2 antibody
JAK2 antibody
JAK2_HUMAN antibody
Janus Activating Kinase 2 antibody
Janus kinase 2 (a protein tyrosine kinase) antibody
Janus kinase 2 antibody
JTK 10 antibody
JTK10 antibody
kinase Jak2 antibody
OTTHUMP00000043260 antibody
THCYT3 antibody
Tyrosine protein kinase JAK2 antibody
Tyrosine-protein kinase JAK2 antibody
more
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应用
ICC: 1:50-1:200
IHC-P: 1:50-1:200
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Fig1: ICC staining JAK2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig2: Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
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