Anti-SOD1 antibody
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概述
- 产品描述Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer's disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.
- 产品名称Anti-SOD1 antibody
- 分子量16 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,FC
- 抗体类型兔多抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified.
- 亚细胞定位Mitochondrion. Nucleus.
- 其它名称ALS antibody
ALS1 antibody
Amyotrophic lateral sclerosis 1 adult antibody
Cu/Zn SOD antibody
Cu/Zn superoxide dismutase antibody
Epididymis secretory protein Li 44 antibody
HEL S 44 antibody
Homodimer antibody
hSod1 antibody
Indophenoloxidase A antibody
IPOA antibody
Mn superoxide dismutase antibody
SOD antibody
SOD soluble antibody
SOD1 antibody
SOD2 antibody
SODC antibody
SODC_HUMAN antibody
Superoxide dismutase [Cu-Zn] antibody
Superoxide dismutase 1 antibody
Superoxide dismutase 1 soluble antibody
Superoxide dismutase Cu Zn antibody
Superoxide dismutase cystolic antibody
more
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应用
WB: 1:500
ICC: 1:500-1:2,000
FC: 1:50-1:100
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Fig1: Western blot analysis of SOD1 on A549 cell lysate using anti-SOD1 antibody at 1/500 dilution.
Fig2: ICC staining SOD1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining SOD1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Flow cytometric analysis of MCF-7 cells with SOD1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
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