Anti-TGF beta 2 antibody
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概述
- 产品描述Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
- 产品名称Anti-TGF beta 2 antibody
- 分子量12/45 KDa
- 种属反应性Rat,Rabbit,Human,Mouse
- 验证应用WB,IHC-P
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human TGF-beta 2 154-197/414
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Secreted.
- 其它名称BSC 1 cell growth inhibitor
BSC1 cell growth inhibitor
Cetermin
G TSF
Glioblastoma derived T cell suppressor
Glioblastoma derived T cell suppressor factor
GTSF
MGC116892
Polyergin
TGF B2
TGF beta2
TGFB 2
TGFB2
Transforming growth factor beta 2.TGF B2
BSC 1 cell growth inhibitor
BSC-1 cell growth inhibitor
BSC1 cell growth inhibitor
Cetermin
G TSF
G-TSF
Glioblastoma derived T cell suppressor
Glioblastoma derived T cell suppressor factor
Glioblastoma-derived T-cell suppressor factor
GTSF
MGC116892
Polyergin
TGF beta2
TGF-beta-2
TGF-beta2
TGFB 2
TGFB2
TGFB2_HUMAN
Transforming growth factor beta 2
Transforming growth factor beta-2.
more
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应用
WB:1:500-2000
IHC-P:1:400-800
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Fig1: Sample:Kidney(Mouse)Lysate at 40 ug
Primary: Anti-TGF beta 2 Propeptideat 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 12'45kD
Observed band size: 50 kD
Fig2: Sample:MCF-7 (Human)Cell Lysate at 40 ug
Primary: Anti-TGF beta 2 Propeptideat 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 12'45kD
Observed band size: 48kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
