Anti-Bcl 2 like 13 protein antibody
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概述
- 产品描述BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the BCL2L13 gene on chromosome 22. This gene encodes a mitochondrially-localized protein which is classified under the Bcl-2 protein family. Overexpression of the encoded protein results in apoptosis. As a result, it has been implicated in cancers such as childhood acute lymphoblastic leukemia (ALL) and glioblastoma multiforme (GBM). Alternatively spliced transcript variants have been observed for this gene, such as Bcl-rambo beta. Bcl-rambo is a member of the Bcl-2 family of proteins that regulate apoptosis. In cells, Bcl-rambo is localized to the mitochondria, and its overexpression induces apoptosis that is blocked by caspase inhibitors, whereas inhibitors controlling upstream events of either the 'death receptor' (FLIP, FADD-DN) or the 'mitochondrial' pro-apoptotic pathway (Bcl-x(L)) had no effect. Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial permeability transition pore, to induce its opening. ANT will also facilitate the transfer of ADP and ATP between the cytosol and the matrix.
- 产品名称Anti-Bcl 2 like 13 protein antibody
- 分子量53 KDa
- 种属反应性Human,Mouse,Chicken,Dog,Pig,Horse,Rabbit
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human Bcl rambo/Bcl 2 like 13 protein 281-380/485
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Isoform 2: Mitochondrion membrane; Single-pass membrane protein (Potential). Nucleus. Isoform 1: Nucleus
- 其它名称Apoptosis facilitator
Bcl 2 like 13
Bcl 2 like 13 protein
BCL2 like 13 apoptosis facilitator
BCL2 like 13
Bcl2 like 13 protein
BCL2L13
MIL 1
MIL1
MIL1 protein
Protein Mil1
B2L13_HUMAN.
more
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Fig1: Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-Bcl 2 like 13 proteinat 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 55 kD
Fig2: Sample:
Pancreas (Mouse) Lysate at 40 ug
Primary: Anti-Bcl 2 like 13 protein at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 55 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
