Anti-LXR alpha + LXR beta antibody
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概述
- 产品描述Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.
- 产品名称Anti-LXR alpha + LXR beta antibody
- 分子量51 KDa
- 种属反应性Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Xenopus laevis
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human LXR alpha + LXR beta 51-150/447
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Nuclear
- 其它名称Liver X receptor alpha
Liver X receptor alpha
Liver X receptor beta
LXR a
LXR
LXR b
LXRa
LXRalpha
LXRb
LXRbeta
NER
NERI
NR1H2
NR1H3
Nuclear orphan receptor LXR alpha
Nuclear orphan receptor LXR beta
Nuclear receptor NER
Nuclear receptor subfamily 1 group H member 2
Nuclear receptor subfamily 1 group H member 3
Oxysterols receptor LXR alpha
Oxysterols receptor LXR beta
RIP15
RLD1
Ubiquitously expressed nuclear receptor
UNR.
more
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Fig1: Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-LXR alpha + LXR betaat 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
